Syeda Tazeen Zehra

My name is Syeda Tazeen Zehra and I have done PhD in Synthetic Organic Chemistry. My PhD research was focused on the development of two asymmetric organic catalytic systems the kinetic resolution of two types of racemic compounds with important application values. At present, the synthesis of these quaternary compounds is challenging by direct asymmetric approaches. . The kinetic resolution of β-ketoesters via intramolecular benzoin coupling reaction catalyzed by N-Heterocyclic carbene affords a series of chiral annulation product and chiral recovered β-ketoesters with good to excellent enantioselectivity. We believe that this research work has good reference significance for the kinetic resolution of more satirically bulky and hindered groups at α-substituted esters (Published in OBCs). The project of classical kinetic resolution of fluorine containing compounds with quaternary carbons, by asymmetric catalytic acyl transfer reaction, and successfully obtained a series of chiral quaternary carbon fluorinated compounds with rich and diverse structures. This method shows an excellent kinetic resolution effect on perfluoro-containing compounds as well (Published in OCF). Other then PhD I have published 3 articles in peered-reviewed journal during my job as research associate in H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University Of Karachi, Pakistan. Mainly my research work was focused on the synthesis of medicinally important compound and drug discovery. As a research associate, many additional responsibilities were also performed including training, supervision and help in the projects of undergraduate or diploma students and new PhD students in setting up their chemical reactions, purification via column chromatography or HPLC and data analysis of their end products. I was also involved organizing the monthly group meetings and managing the laboratory accessories.